Clinical Scientist inLondon inLondon PUBLISHED 21 MAY 2024

BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experience.
Job summary

Our scientific teams have developed significant expertise and have established close working relationships with our clinical colleagues to ensure that our patients benefit from the information generated by WGS. To be able to grow the service and enable prompt adoption of testing in newly-eligible tumour types, we are now looking for a Clinical Scientists to join our team dedicated to the WGS service.

The main focus of the role will be the analysis and interpretation of WGS data for cancer patients (solid and haematological malignancies in both paediatric and adult patients) and presentation of the findings to scientists, clinicians, clinical geneticists and genetic counsellors at our regular Genomic Tumour Advisory Boards (GTABs). Working across the North-Thames GLH, WGS-scientists will interact with scientific and clinical colleagues from the GLH as well as the partner laboratories and referring hospitals to support a pan-GLH service.

An understanding of and proficiency in variant classification for somatic and/or germline findings according to published guidelines is required and experience in analysis of complex genetic data, e.g. from WGS (including the 100K project), would be an advantage.

We welcome applications from registered clinical scientist working in cancergenomics or genetics with an interest in acquired diseases.

It is anticipated thatinterviews will be held week commencing 24th June.

Main duties of the job

To follow established procedures and protocols

Comply with health and safety policies

Comply with corporate and professional codes of conduct

Assist in quality assurance procedures

Assist in training of new staff or visitors

To generate and interpret results, to classify genomic variants, to calculate risks where necessary, and to produce clear and concise patient reports adhering to agreed templates and sample turnaround times as directed by the Head of Service. The focus of this role will be on the analysis of whole-genome sequencing analysis with presentation of cases at GTAB and issuing of reports

To participate in the training and supervision of other members of staff and visitors

To prepare for and participate in multidisciplinary meetings with other members of staff, clinicians and staff from other scientific disciplines as required.

To undertake additional responsibilities as directed by the Head of Service, for example Deputy Safety Officer

About us

GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.

We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.

We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.

We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women's staff networks.

Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust's mission, values and efforts specific to inclusion. All of our staff networks are open to any employee

Job description

Job responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below

Job description
Job responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below

Person Specification

GOSH Culture and Values

Essential

  • Our Always values
Academic/Professional qualification/Training

Essential

  • BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experience
  • HCPC Clinical Scientist Registration Certificate
Desirable

  • Postgraduate qualification in Genomics
Experience/Knowledge

Essential

  • Experience working in a clinical diagnostics/ genomics laboratory
  • Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
  • Experience of writing clinical genetics reports
  • Knowledge and experience of molecular variant classification in accordance with relevant guidelines including analysis of complex variants including CNV and structural variants from next-generation sequencing data
  • Track record of scientific Publications/ presentations
Desirable

  • Experience in the analysis and reporting of whole genome sequencing data
  • Evidence of supervising/training other staff
  • Experience with laboratory information and quality management systems
Skills/Abilities

Essential

  • Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / Microarray
  • Good organisational and interpersonal skills. Willing to adapt to changes in workflow and organisation
  • Computer literate, including use of Genetic databases, analytical software, variant classification
  • Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
  • Able to write protocols
Desirable

  • Background in cytogenetic and molecular procedures
Person Specification
GOSH Culture and Values

Essential

  • Our Always values
Academic/Professional qualification/Training

Essential

  • BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experience
  • HCPC Clinical Scientist Registration Certificate
Desirable

  • Postgraduate qualification in Genomics
Experience/Knowledge

Essential

  • Experience working in a clinical diagnostics/ genomics laboratory
  • Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
  • Experience of writing clinical genetics reports
  • Knowledge and experience of molecular variant classification in accordance with relevant guidelines including analysis of complex variants including CNV and structural variants from next-generation sequencing data
  • Track record of scientific Publications/ presentations
Desirable

  • Experience in the analysis and reporting of whole genome sequencing data
  • Evidence of supervising/training other staff
  • Experience with laboratory information and quality management systems
Skills/Abilities

Essential

  • Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / Microarray
  • Good organisational and interpersonal skills. Willing to adapt to changes in workflow and organisation
  • Computer literate, including use of Genetic databases, analytical software, variant classification
  • Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
  • Able to write protocols
Desirable

  • Background in cytogenetic and molecular procedures
Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .

From 6 April 2, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
UK Registration

Applicants must have current UK professional registration. For further information please see

Additional information
Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .

From 6 April 2, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
UK Registration

Applicants must have current UK professional registration. For further information please see

Employer details

Employer name

Great Ormond Street Hospital for Children NHS Foundation Trust
Address

Great Ormond Street Hospital for Children NHS Foundation Trust

Great Ormond Street Hospital

London

WC1N 3JH

Employer's website
Job summary

Our scientific teams have developed significant expertise and have established close working relationships with our clinical colleagues to ensure that our patients benefit from the information generated by WGS. To be able to grow the service and enable prompt adoption of testing in newly-eligible tumour types, we are now looking for a Clinical Scientists to join our team dedicated to the WGS service.

The main focus of the role will be the analysis and interpretation of WGS data for cancer patients (solid and haematological malignancies in both paediatric and adult patients) and presentation of the findings to scientists, clinicians, clinical geneticists and genetic counsellors at our regular Genomic Tumour Advisory Boards (GTABs). Working across the North-Thames GLH, WGS-scientists will interact with scientific and clinical colleagues from the GLH as well as the partner laboratories and referring hospitals to support a pan-GLH service.

An understanding of and proficiency in variant classification for somatic and/or germline findings according to published guidelines is required and experience in analysis of complex genetic data, e.g. from WGS (including the 100K project), would be an advantage.

We welcome applications from registered clinical scientist working in cancergenomics or genetics with an interest in acquired diseases.

It is anticipated thatinterviews will be held week commencing 24th June.

Main duties of the job

To follow established procedures and protocols

Comply with health and safety policies

Comply with corporate and professional codes of conduct

Assist in quality assurance procedures

Assist in training of new staff or visitors

To generate and interpret results, to classify genomic variants, to calculate risks where necessary, and to produce clear and concise patient reports adhering to agreed templates and sample turnaround times as directed by the Head of Service. The focus of this role will be on the analysis of whole-genome sequencing analysis with presentation of cases at GTAB and issuing of reports

To participate in the training and supervision of other members of staff and visitors

To prepare for and participate in multidisciplinary meetings with other members of staff, clinicians and staff from other scientific disciplines as required.

To undertake additional responsibilities as directed by the Head of Service, for example Deputy Safety Officer

About us

GOSH is committed to recruiting the best person for the job, based solely on their ability and individual merit as measured against the criteria for the role; through a process that is fair, open, consistent and free from bias and discrimination.

We are committed to being a diverse and inclusive employer and foster a culture where all staff are valued, respected and acknowledged. All applicants will receive consideration for employment without regard to race, colour, national origin, religion, sexual orientation, gender, gender identity, age, disability status or length of time spent unemployed.We particularly welcome applications from BAME communities, people with disabilities and/or long-term health conditions and LGBT+ community members.

We have policies and procedures in place to ensure that all applicants and employees are treated fairly and consistently. We are proud to be accredited as a Disability Confident Employer, a member of Business Disability Forum and a Stonewall Diversity Champion.

We have active and Executive supported BAME, LGBT+ and Allies, Disability and Long-Term Health Conditions and Women's staff networks.

Staff networks are employee-led groups formed around interests, issues and a common bond or background. Staff network members create a positive and inclusive work environment at Great Ormond Street Hospital by actively contributing to the Trust's mission, values and efforts specific to inclusion. All of our staff networks are open to any employee

Job description

Job responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below

Job description
Job responsibilities

The full job description provides an overview of the key tasks and responsibilities of the role, and the person specification outlines the qualifications, skills, experience and knowledge required. For both documents please view the attachment/s below

Person Specification

GOSH Culture and Values

Essential

  • Our Always values
Academic/Professional qualification/Training

Essential

  • BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experience
  • HCPC Clinical Scientist Registration Certificate
Desirable

  • Postgraduate qualification in Genomics
Experience/Knowledge

Essential

  • Experience working in a clinical diagnostics/ genomics laboratory
  • Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
  • Experience of writing clinical genetics reports
  • Knowledge and experience of molecular variant classification in accordance with relevant guidelines including analysis of complex variants including CNV and structural variants from next-generation sequencing data
  • Track record of scientific Publications/ presentations
Desirable

  • Experience in the analysis and reporting of whole genome sequencing data
  • Evidence of supervising/training other staff
  • Experience with laboratory information and quality management systems
Skills/Abilities

Essential

  • Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / Microarray
  • Good organisational and interpersonal skills. Willing to adapt to changes in workflow and organisation
  • Computer literate, including use of Genetic databases, analytical software, variant classification
  • Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
  • Able to write protocols
Desirable

  • Background in cytogenetic and molecular procedures
Person Specification
GOSH Culture and Values

Essential

  • Our Always values
Academic/Professional qualification/Training

Essential

  • BSc Honours degree in an appropriate biological science with a substantial genetics component or alternative qualifications and equivalent experience
  • HCPC Clinical Scientist Registration Certificate
Desirable

  • Postgraduate qualification in Genomics
Experience/Knowledge

Essential

  • Experience working in a clinical diagnostics/ genomics laboratory
  • Extensive knowledge of clinical genomics and a demonstrable track record in the delivery of a diagnostic service
  • Experience of writing clinical genetics reports
  • Knowledge and experience of molecular variant classification in accordance with relevant guidelines including analysis of complex variants including CNV and structural variants from next-generation sequencing data
  • Track record of scientific Publications/ presentations
Desirable

  • Experience in the analysis and reporting of whole genome sequencing data
  • Evidence of supervising/training other staff
  • Experience with laboratory information and quality management systems
Skills/Abilities

Essential

  • Skilled in Next Generation Sequencing Applications / Sanger Sequencing and/or genomic CNV analysis by use of G banded chromosomes / FISH / Microarray
  • Good organisational and interpersonal skills. Willing to adapt to changes in workflow and organisation
  • Computer literate, including use of Genetic databases, analytical software, variant classification
  • Able to communicate effectively both verbally and in writing (by email and by appropriate documentation)
  • Able to write protocols
Desirable

  • Background in cytogenetic and molecular procedures
Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.
Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .

From 6 April 2, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
UK Registration

Applicants must have current UK professional registration. For further information please see

Additional information
Certificate of Sponsorship

Applications from job seekers who require current Skilled worker sponsorship to work in the UK are welcome and will be considered alongside all other applications. For further information visit the .

From 6 April 2, skilled worker applicants, applying for entry clearance into the UK, have had to present a criminal record certificate from each country they have resided continuously or cumulatively for 12 months or more in the past 10 years. Adult dependants (over 18 years old) are also subject to this requirement. .
UK Registration

Applicants must have current UK professional registration. For further information please see

Employer details

Employer name

Great Ormond Street Hospital for Children NHS Foundation Trust
Address

Great Ormond Street Hospital for Children NHS Foundation Trust

Great Ormond Street Hospital

London

WC1N 3JH

Employer's website


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